Chinese name: penicillin acylase (also known as penicillin amidase or penicillin aminohydrolase)
English name: Penicillin acylase
Activity: ≥ 240U/G
It is mainly obtained from the intracellular enzyme of Escherichia coli and the extracellular enzyme of Bacillus megaterium, which has been widely used in industrial production β- Key intermediates and semi-synthesis of lactam antibiotics β- Lactam antibiotics.
Penicillin acylase (PA) is widely used in industry to prepare 6APA from penicillin as a semi-synthetic enzyme β- The precursor of lactam antibiotics. In recent years, its highly selective property of p-phenylacetic acid group makes it not only be used to catalyze the hydrolysis of penicillin, but also to catalyze the reaction of other amines, peptides and alcohols
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